SOD2 and Parkinson disease: By exposing DAergic cells to pan-nitrating reagents, certain nitrated proteins have been detected in DA neurons, including protein kinase C [20], catecholamines [21], manganese superoxide dismutase [22], α-synuclein [23]–[25], which demonstrated the possible importance of nitrated stress in the etiology of PD both in vitro and in vivo.