PROM1 and cancer: Figure 1D shows that following an optimized protocol of cell culture in the HFB, it is possible to select and to proliferate a specific population contained in the SAOS-2 parental cell line. Similar results were achieved using various other cancer cell lines of different tissue origin and which express a variable amount of the CD133 marker (HOS, U2OS, T98G, U87MG, Du145, LNCap, WI38, H23, Hep3b, Hela, Mewo, HO-1 cells, HN12 and HN30), see Table 1, and data not shown.