Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophic and neuroprotective peptide that has been shown to exert protective effects in different neuronal injuries, such as traumatic brain and spinal cord injury, models of neurodegenerative diseases and cerebral ischemia [102–104]. The gene discussed is ADCYAP1; the disease is neurodegenerative disease.