Our findings illustrate that there is a greater nuclear translocation of the NF-κB protein p65 in chorionic villi and deciduas from women with early spontaneous miscarriage, but a significant increase was observed in villous stromal cells, decidual glandular epithelial cells, decidual stromal cells and decidual vessel endothelial cells compared to viable pregnancies. The gene discussed is RELA; the disease is Miscarriage.