Plasma from AAS patients contains not only IL-10 and cortisol, but also other molecules that can differentially modulate the expression of HLA-DR, including cytokines (TNFα, TGFβ), translocated PAMPs, neuromediators, mediators of inflammation (PGE2) and stress (ACTH). The gene discussed is POMC; the disease is Aarskog-Scott syndrome, X-linked.