In addition, several strong correlations were found between the infiltration of lymphocytes and clinicopathological variables, such as poorly differentiated tumors (CD8+ in stroma and cancer cells, CD3+ and granzyme B in invasive margin), distal location (CD3+ in cancer cells and granzyme B in invasive margin), early stage (CD8+ in cancer cells, CD3+ in invasive margin and cancer cells and granzyme B in cancer cells) and the absence of treatment (CD8+ in all areas CD3+ and granzyme B in invasive margin and stroma). The gene discussed is GZMB; the disease is cancer.