It is shown that infiltration of CD3+ T cells is most abundant in the invasive margin while infiltration of CD8+ cytotoxic T lymphocytes is strongest in the invasive margin and the stroma which means that in this study population, most T lymphocytes were found in the invasive margin but the cytotoxic T lymphocytes were also abundant in the stroma close to the tumor cells. This evidence concerns the gene CD8A and neoplasm.