Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) usually regulate polyamine metabolism and inhibitors against these enzymes are being applied in diverse therapies ranging from tumour suppressors to the treatment of West African sleeping sickness (Trypanosoma brucei gambiense), validating polyamine metabolism as a target for drug intervention in these protozoan parasites [1]. The gene discussed is ODC1; the disease is neoplasm.