In summary, this study provides evidence that variation in FAM5C might contribute to aggressive periodontitis, and that the markers rs1935881 and rs1342913 are candidate functional variants (based on multispecies nucleotide sequence comparisons and electronic transcription binding site predictions - Figure 1 and Table S6) or are in linkage disequilibrium with still unknown disease-predisposing alleles. Here, BRINP3 is linked to periodontitis.