While further experiments are needed to clarify cdr2 function in spindle biology and whether those effects are independent of or connected to cdr2 regulation of c-myc-dependent transcription, these observations suggest a model (Fig. 9) in which cdr2 acts during mitosis, in part through interactions with c-myc, to regulate a cascade of actions related to tumor cell growth. Here, CDR2 is linked to neoplasm.