TCHP and cancer: Furthermore, given the loss of function of tumor suppressor proteins coinciding with an oncoprotein metastasis and its (epi)genetic correlates (Fig. 2b), drug treatment of cancer disease could equally undergo a paradigm shift through the application of cell-permeable tumor suppressor peptides that enter both morphologically normal, yet likely premalignant cells and cancer cells (Fig. 2c), as previously envisaged [17,18,39,40,44].