CRP and bacterial infectious disease with sepsis: Periodontal pathogens do not induce only local inflammation and tissue destruction; they are involved in systemic increase in inflammatory and immune response.[13] Low levels of bacteremia, LPS, and other bacterial components may provide a stimulus for systemic inflammatory responses such as increased production of CRP due to activation of the cascade of inflammatory cytokines production by monocytes and other cells in periodontal tissues.[14]