Curcumin (1%) as subgingival irrigant resulted in significant reduction in bleeding on probing (100%) and redness (96%), when compared with chlorhexidine and saline group as an adjunctive therapy in periodontitis patients.[17] Because curcumin-induced apoptosis is decreased by insulin as shown in the present study, curcumin as subgingival irrigant will be a novel approach for diabetic patients (on insulin therapy) in the treatment of periodontitis. The gene discussed is INS; the disease is periodontitis.