ANGPT2 and central nervous system cancer: As Ang-2 signaling has been implicated in mediating blood vessel co-option in the untreated early C6 rat glioma model of malignant glioma [10], human GBM tumors were immunostained for Ang-1 and Ang-2 and it was reported that Ang-2 expression was upregulated at tumor co-opted blood vessels.