SLC4A1 and cerebral malaria: High frequency of general heterozygosity (0.175) of Myg1 Arg4Gln can also be a target of natural selection, similarly with 9-amino acid deletion in SLC4A1 gene that is completely lethal in the homozygous state [21], but heterozygosity persists with a maximum frequency of 0.175 due to a protective effect with respect to cerebral malaria in Southeast Asia.