BMI1 and ovarian carcinoma: FISH results demonstrated that the amplification of Bmi-1 was not detected in any of the ovarian cystadenoma and borderline tumor tissues; but was detected in 8% (8/96) of the informative ovarian carcinomas; in each of the 8 cases with Bmi-1 amplification, intensive expression of Bmi-1 was observed (Fig. 1E and 1F).