BMI1 and colorectal cancer: It has been confirmed that Bmi-1 gene is widely expressed in diverse human tumors, including non-small cell lung cancer, hepatocellular carcinoma, B-cell non-Hodgkin's lymphoma, breast cancer, ovarian cancer, colorectal cancer, skin cancer and neuroblastoma [10-20], and has been shown to be a useful prognostic marker in myelodysplastic syndrome and many cancers, including nasopharyngeal carcinoma, bladder cancer and gastric cancer [17-20].