ACE and heart failure: There was no difference in overall mortality between patients treated with combination therapy compared to ACE inhibitor therapy alone (RR 0.97, 95%CI 0.92–1.03, p-value for heterogeneity = 0.49; I2 = 0% [95%CI 0–68%]) [Figure 2 - mortality and cardiovascular outcomes in randomized controlled trials comparing angiotensin receptor antagonists and ACE inhibitors versus ACE inhibitors alone in patients with heart failure].