There were fewer patients with combination therapy compared to ACE inhibitor therapy with hospital admissions due to congestive heart failure (RR 0.81, 95%CI 0.72–0.91; p-value for heterogeneity = 0.04; I2 = 57% [95%CI 0–83%]), but there was no difference between groups for hospitalization for any reason (RR 0.92, 95% CI 0.82–1.05; p-value for heterogeneity <0.001, I2 = 91% [95%CI 81–95%]). This evidence concerns the gene ACE and congestive heart failure.