A cohort of 107 subjects with a history of steroid-induced ocular hypertension (steroid-responders), 197 POAG patients, and 400 control subjects from Iowa were genotyped at a total of 48 SNPS in SFRS3, SFRS5, SFRS9, FKBP4, FKBP5, and NR3C1. Given the size of our cohort, we have adequate power under most conditions to detect powerful risk factors for the steroid response or POAG that have an odds ratio of greater than 1.75. Here, FKBP4 is linked to open-angle glaucoma.