Consistent with the above-proposed model, the unbiased analysis of biological modulators associated with networks formed by genes with altered amygdala-cingulate coregulation, identified factors previously implicated in depression or in its treatment (insulin, beta-estradiol, thyroid hormone, IL1 and glucocorticoids; Table 1), although notably, none of them would be sufficient to reasonably explain the presence of the illness in heterogeneous clinical cohorts [1], [24]. The gene discussed is INS; the disease is major depressive disorder.