Both infants required further intervention by exchange transfusions.[10] In the exchange transfusion practice with G6PD-deficient blood, a lesser drop in post-exchange total serum bilirubin, prolongation of the duration of phototherapy, the need for repeat exchange transfusions and occurrence of massive intravascular hemolysis in infants have also been reported.[11–13] The above complications have been reported in patients with normal G6PD activity. Here, G6PD is linked to hemolysis.