BACE1 and Alzheimer disease: In a recent studyfrom our laboratory, we reported similar observations in an animal model of AD(APPSwe/PS1 mice) and demonstrated a role for two miRNAs, i.e. miR-298 andmiR-328, in the regulation of BACE1 expression, using mainly transientlytransfected murine neuronal N2a cells in culture [8].