BACE1 and Alzheimer disease: In vivo, we observeddecreased expression levels of miR-298 and miR-328 in the hippocampus of agingAPPSwe/PS1 mice [8], which supports further the possibility that the loss ofmiRNA regulation of BACE1 mRNA translation may lead to higher BACE1 proteinexpression, an enhanced Aß formation and the development of AD.