In particular, the FOS protein is induced by CC3 in HepG2 but not in U373 (Figure 4B); nucleoredoxin is downregulated by CC3 in three tumor cell lines but not in U373 (Figure 6D); vimentin, whose RNA is upregulated 300 fold in U373cc3 cells (Additional File 2) is practically unchanged at the protein level, but is strongly induced in N417 cells (data not shown). Here, NXN is linked to neoplasm.