CC3 is a phylogenetically conserved protein whose expression is absent or much reduced in a variety of aggressive or metastatic tumors such as vSCLC [1], neuroblastoma and glioblastoma [2,3], metastatic breast cancer [4], gastric cancer [5], hepatocellular carcinoma [6,7], colorectal carcinomas [8] and lung cancers with poor prognosis [9]. Here, HTATIP2 is linked to neuroblastoma.