Moreover, in two models of systemic lupus erythematosus, PI3Kγ was shown to control the CD4+ memory T cell reservoir mostly in the context of a second genetic alteration (MRL-lpr or p65PI3KTg), while single-targeted PI3Kγ-inhibition revealed only modest phenotypes [27,29]. Here, CD4 is linked to systemic lupus erythematosus.