We show that lgl-/- clonal phenotype strictly depends on dMyc oncoprotein levels: when lgl-/- cells have lower levels of dMyc with respect to the surrounding tissue, their clonal growth is restricted by JNK-mediated apoptosis, whereas when lgl-/- cells have high levels of dMyc, mutant clones survive and proliferate to form invasive tumours. The gene discussed is MAPK8; the disease is neoplasm.