ITGB4 and cancer: Among miR-204 gene targets that are potential regulators of cell-matrix interaction and proteolysis, overexpression of APRC1B [34], CTSC [35], FAP [36], MMPs [37], BMP1 [38], CDH11 [39] and ITGB4 [40] is associated with cancer metastasis and/or poor prognosis.