PTEN and Insulin resistance: Similarly, the basal level phosphorylation of mTOR (Ser 2448), Akt (Ser 308), GSK-3β (Ser 9), and PTEN (Ser 380/Thr 382/383) was 63.0%, 25.1%, 17.5% and 31.4% higher, respectively, with insulin resistance (P  <  .05) (Figures 3–6).