CTNNB1 and endometrial carcinoma: Although there was a good correlation between CTNNB1 mutations and β-catenin nuclear immunostaining, the presence of cytoplasmic and nuclear β-catenin immunoreactivity in some endometrial carcinomas without CTNNB mutation suggests that the changes of other genes in the Wnt/β-catenin/LEF-1 pathway may be responsible for the stabilization and putative transcription activator role of β-catenin [7, 8].