In a previous study, analysis of PCBP1 expression in different grade squamous intraepithelial lesions, and invasive cervical carcinoma showed that PCBP1 expression decreased in high grade squamous intraepithelial lesions and cancer, respectively and the loss of PCBP1 expression may allow HPV infected cervical tissues to undergo virus mediated transformation from cervical dysplasia to cancer [19]. This evidence concerns the gene PCBP1 and squamous cell intraepithelial neoplasia.