TGFBI and Reis-Bücklers corneal dystrophy: TGFBI has been closely involved with the inherited corneal dystrophies, as mutations in this gene were identified in at least 5 types of corneal dystrophies, including granular corneal dystrophy (R555W), Avellino corneal dystrophy (R124H), lattice corneal dystrophy type I (R124C), Thiel-Behnke corneal dystrophy (R555L), and RBCD (R124L, G623D) [10,19].