Having found that Bax remained bound to the mitochondrial OM even after a wash with an alkaline homogenization buffer (pH 11.6) (not shown) suggesting an insertion of Bax into the membrane [32], we further wanted to examine if ABT-737 might induce oligomerization of the Bax and Bak pools already associated to tumor cell mitochondria. The gene discussed is BAK1; the disease is neoplasm.