Among various compounds (from chemical, peptidic or proteic origins) described to target mitochondria, we found that only recombinant t-Bid, Bak BH3 and Bim BH3 peptides, and ABT-737 present a direct tumor-specific mitochondrio-toxicity and induce relatively large OMP due to Bax and Bak oligomerization. This evidence concerns the gene BAK1 and neoplasm.