IL6 and Miyoshi myopathy: Because most MM cell lines grow rapidly and disseminate extraosseously in SCID mice, we utilized an IL-6 or stromal cell-dependent human MM cell line, INA6, which has been shown to hardly grow subcutaneously but grow within a human fetal bone implanted in SCID mice (SCID-hu mice).[27] SCID-rab mice have been developed to substitute for SCID-hu mice to recapitulate MM expansion within the bone marrow and formation of a bone disease.[28] Therefore, we generated SCID-rab MM models using INA6 cells.