TGFB1 and Miyoshi myopathy: 2008;23 abstract F275) as well as normal mice.[41] Pharmacological blockade of TGF-β action by the anti-TGF-β monoclonal antibody 1D11 has also been demonstrated to reduce serum M-protein levels as well as improve bone volume and strength in 5TGM1-bearing mouse MM models (Hart AJ, Fowler JA, Lwin ST, et al. J Bone Miner Metab.