Treatment of MCF-7 cells with mevastatin resulted in a 10- to 15-fold induction of HMG-CoAR activity in association with a 2.5- to 3.5-fold induction of HMG-CoA reductase mRNA expression [28], suggesting that treatment with statins may increase tumour specific HMG-CoAR expression in vivo, however this remains to be fully elucidated. Here, HMGCR is linked to neoplasm.