This study sought possible differences in the expression of the anti-apoptotic BI-1 and pro-apoptotic Bax factors in liver tissues from patients with different severity of liver damage, from chronic viral hepatitis to cirrhosis and finally HCC, with a view to examining its biological role in the progression of liver disease towards cancer, naturally history in which little is known about the expression of BI-1 and Bax. Here, TMBIM6 is linked to animal viral hepatitis.