In order to investigate the dynamic changes of tau, p-tau (Ser396), p-tau (Ser404), p-tau (Ser202/Thr205), GSK3β and CDK5 in the brains of scrapie-infected hamsters during incubation period, the expressive and transcriptional levels of these biomarkers were evaluated by Western blots and real-time PCR, respectively. The gene discussed is MAPT; the disease is scrapie.