Using an appropriately matched cohort approximately ten times the size of the Patti et al. study [2], we establish that the T2D global muscle coding-RNA transcriptome is invariant, while our subgroup analysis, designed to be comparable with Mootha et al. [1], demonstrates that their observation of a reduced OXPHOS gene set in T2D patients appears to reflect the acute differential response to pharmacological levels of insulin [80] in their control subjects, or some other confounding drug treatment in their diabetes patients (for example, statin therapy). Here, INS is linked to diabetes mellitus.