Within the top 20 genes ranked by Notch pathway-guided COCA (Table S12(a)), there are several genes related to differentiation (Tdgf1, Egr1 and Lefty1), cell growth (Ddit4, Hk2, Phlda2, Egln3 and Igfbp1) and tumor/cancer development (Afp, Sfrp2, Egr1, Hk2 and Phlda2). The gene discussed is CRIPTO; the disease is cancer.