Because Mtb72f is a polyprotein containing several non-TB potential epitopes at the junction of the PPE18 and PepA proteins and at the N-terminus of the polyprotein, we investigated whether epitopes present in the Mtb72f vaccine but not in the native PPE18 and PepA proteins might misdirect the immune response upon immunization. This evidence concerns the gene CNDP2 and tuberculosis.