Thus, HLA-DRB1 SE alleles (OR = 2.1 (1.9 to 2.4), P < 0.0001), PTPN22 (OR = 1.5 (1.3 to 1.8), P < 0.0001), OLIG3/TNFAIP3 (OR = 1.2 (1.0 to 1.4), P = 0.009) and TRAF1/C5 (OR = 1.1 (1.0 to 1.3), P = 0.035) were associated with RA. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.