Based on the critical role of GLUT4 in glucose homeostasis, and the association of hyperglycemia with metabolic disorders such as insulin resistance, type-2 diabetes, dyslipidaemia, hypertension and obesity [4], [5], structural and functional studies of GLUT4 have received great attention: a Pubmed search using the query “GLUT4 and glucose transporter” reports 250 publications in 2008 and 940 during the 2004–2008 quinquennium. Here, SLC2A4 is linked to type 2 diabetes mellitus.