Based on the critical role of GLUT4 in glucose homeostasis, and the association of hyperglycemia with metabolic disorders such as insulin resistance, type-2 diabetes, dyslipidaemia, hypertension and obesity [4], [5], structural and functional studies of GLUT4 have received great attention: a Pubmed search using the query “GLUT4 and glucose transporter” reports 250 publications in 2008 and 940 during the 2004–2008 quinquennium. This evidence concerns the gene SLC2A4 and inherited lipid metabolism disorder.