There was no significant different serum apoA-I levels among patients with CIS (1.422 ± 0.091 g/L; P = 0.177), GBS (1.260 ± 0.093 g/L; P = 0.978), viral encephalitis(1.062 ± 0.080 g/L;P = 0.067) and healthy subjects (1.112 ± 0.070 g/L; P = 0.142). This evidence concerns the gene APOA1 and Guillain-Barre syndrome.