Although larger studies would be required to reach formal significance and confirm the relevance of DOCK4 to reading ability, it is worth noting that 1) case-control analysis does not consider the segregation seen, and 2) a previous study of 11 large Finnish dyslexia pedigrees detected linkage at 7q32 (maximum nonparametric genome-wide linkage score of 2.77) 17.4 Mb distal to DOCK4 (39). Here, DOCK4 is linked to dyslexia.