We propose these results warrant re-evaluation of the very definition of "trastuzumab resistance." Moreover, since so-called 'resistant' EOC cells are, in fact, primed by trastuzumab to acquire de novo sensitivity to other HER-targeted therapeutics, we propose that these results provide the rationale for re-evaluation of trastuzumab as an experimental ovarian cancer therapeutic, perhaps as a priming agent for EGFR-targeted drugs. Here, EGFR is linked to ovarian cancer.