Examples of these novel drugs include imatinib (Gleevec), trastuzumab (Herceptin), gefitinib (Iressa) and erlotinib (Tarceva), cetuximab (Erbitux) and panitumumab (Vectibix), and sunitinib (Sutent), which have been FDA approved for the treatment of chronic myelogenous leukemia, HER2-positive breast cancer, non-small cell lung cancer, colorectal cancer, and gastrointestinal stromal and advanced kidney cancer, respectively. The gene discussed is ERBB2; the disease is breast carcinoma.