Many macroscopic and microscopic parametres have been suggested to identify the prognosis, including tumor localization and diameter, invasion of peripheral tissue, growth pattern, mucosal invasion, predominant tumor cell type, cellularity, nuclear pleomorphism, mitotic count, Ki67 proliferative activity index, p53 gene mutation, histological grade, DNA analysis, margins of surgical operation, necrosis and immunophenotyping [1-7]. This evidence concerns the gene TP53 and neoplasm.