Therefore, overexpression of p16INK4A, as detected by immunohistochemistry, has shown to be a useful adjunct to cytology in cervical cancer screening [22], a reliable marker of human papillomavirus-induced oral high-grade squamous dysplasia [23], and a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia [24]. This evidence concerns the gene CDKN2A and cervical cancer.