The p53 expression in HRS cells were assessed and shown in 36 (72%) cases among the 50 CHL patients in the study of Gupta et al., in all of the 67 CHL patients in the study of Magio et al. and in 14 (42%) cases among the 33 CHL patients in the study of Ohsawa et al. [7,16,19]. This evidence concerns the gene TP53 and classic Hodgkin lymphoma.