Corresponding to the low-grade glioma tissues in our present study, H4 is a neuroglioma cell line derived from a low-grade malignant glioma [31-33] to take as an internal standard for protein relative quantification in MS [27], which was proved to express all of HSP proteins those were identified in human glioma tissues. This evidence concerns the gene HSP90B2P and malignant glioma.