Taken together, these data reported in glioma cells indicate that PPARγ activation by both synthetic and natural ligands, results in cell cycle arrest, apoptosis promotion, inhibition of cell migration and invasion as well as suppression of antiapoptotic proteins, induction of differentiation markers, thus suggesting their potential use in the formulation of new therapeutic strategies against this neoplasm and recurrences. This evidence concerns the gene PPARG and central nervous system cancer.