Chang et al. reported that PGE2 prevented apoptosis induced by NGF (nerve growth factor) withdrawal by increasing the level of dynein light chain, an inhibitor of neuronal NO synthase in pheochromocytoma of the rat adrenal medulla PC12 cells, thus leading to decreased intracellular NO levels [108]. This evidence concerns the gene NGF and hereditary pheochromocytoma-paraganglioma.