Hostanska et al. used human colon COX-2-positive HT 29 and COX-2-negative HCT 116 or lung COX-2 proficient A 549 and low COX-2 expressing SW2 cells and showed that willow bark extract BNO 1455 and its fractions inhibit the cell growth and promote apoptosis in human colon and lung cancer cell lines irrespective of their COX selectivity [167]. The gene discussed is PTGS2; the disease is lung cancer.