PTGS2 and cancer: Data suggested that COX-2 may play a role in different steps of cancer progression, by increasing proliferation of mutated cells [30], thus favoring tumor promotion as well as by affecting programmed cell death and affecting the efficacy of anticancer therapies [35–39] to be, finally, implicated in metastasis formation, for example, by affecting apoptosis induced by loss of cell anchorage (anoikis) [40].