ALS2/alsin is an activator for the small GTPase Rab5 [15], and involves not only in early endosome/macropinosome trafficking and fusion [16], [17] but also in neuroprotection against MND-associated pathological insults, such as toxicity induced by mutant SOD1 [25], [46]. Here, RAB5A is linked to mild neurocognitive disorder.