In agreement with the in silico transcript analysis, there was a significantly higher proportion of Endo180 positive cases in grade IV GBM (59/69, 85.5%) compared to the grade III lesions anaplastic astrocytoma (1/5, 20%) or anaplastic oligodendroglioma (2/5, 40%) (Table 1, grade IV versus grade III, p = 0.0005, Fishers exact test). Here, MRC2 is linked to anaplastic astrocytoma.