TNF and acute myeloid leukemia: For example, the transcription factors C/EBPα, involved in myeloid cell differentiation [62] and associated with acute myeloid leukemias [63], and MHC2TA (CIITA), the major regulator controlling expression of MHC class II molecules [50], were both preferentially induced by type II IFN (in PBMCs compared to type I IFNs and TNFα).